doi: 10.1073/pnas.75.4.2008.
Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells
- PMID: 205877
- PMCID: PMC392472
- DOI: 10.1073/pnas.75.4.2008
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Transforming activity of Epstein-Barr virus obtained by superinfection of Raji cells
Proc Natl Acad Sci U S A.
1978 Apr.
Abstract
Epstein-Barr virus obtained by superinfection of Raji cells with Epstein-Barr virus recovered from P3HR1 cells (HRI virus) transformed human lymphocytes, but it did not superinfect Raji cells. A human lymphoblastoid cell line, HLB, established by such transformation contained 22 Epstein-Barr virus genomes per cell and Epstein-Barr virus-associated nuclear antigen, and a few cells contained early or viral capsid antigen complexes. Chromosomal analysis revealed that HLB-cells were diploid with normal female karyotypes. Replication of Epstein-Barr virus DNA and inhibition of host cell DNA synthesis were observed in HLB cells after superinfection with HR1 virus.
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