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. 2010 Jul;33(7):1491-3.
doi: 10.2337/dc09-2215.

Diabetes and the severity of pandemic influenza A (H1N1) infection

Robert Allard  1 , Pascale Leclerc, Claude Tremblay, Terry-Nan Tannenbaum
Affiliations

Diabetes and the severity of pandemic influenza A (H1N1) infection

Robert Allard et al. Diabetes Care. 2010 Jul.

Abstract

Objective: To confirm the existence of an increased risk of complications from influenza A (H1N1)p among patients with diabetes.

Research design and methods: Using data from an enhanced influenza surveillance project in Montreal, Canada, and age/sex-specific population estimates of diabetes prevalence, we estimated the risk of hospitalization among persons with diabetes. Comparing hospitalized patients admitted or not to an intensive care unit (ICU), we estimated the risk of ICU admission associated with diabetes, controlling for other patient characteristics.

Results: Among 239 hospitalized patients with PCR-confirmed influenza A (H1N1)p, 162 (68%) were interviewed, of whom 22 had diabetes, when 7.1 were expected (prevalence ratio 3.10 [95% CI 2.04-4.71]). The odds ratio for ICU admission was 4.29 (95% CI 1.29-14.3) among hospitalized patients with diabetes compared to those without.

Conclusions: Diabetes triples the risk of hospitalization after influenza A (H1N1)p and quadruples the risk of ICU admission once hospitalized.

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References

    1. Muller LM, Gorter KJ, Hak E, Goudzwaard WL, Schellevis FG, Hoepelman AI, Rutten GE: Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus. Clin Infect Dis 2005; 41: 281–288 - PubMed
    1. Valdez R, Narayan KM, Geiss LS, Engelgau MM: Impact of diabetes mellitus on mortality associated with pneumonia and influenza among non-Hispanic black and white US adults. Am J Public Health 1999; 89: 1715–1721 - PMC - PubMed
    1. Orzeck EA, Shi N, Blumentals WA: Oseltamivir and the risk of influenza-related complications and hospitalizations in patients with diabetes. Clin Ther 2007; 29: 2246–2255 - PubMed
    1. Fiore AE, Shay DK, Broder K, Iskander JK, Uyeki TM, Mootrey G, Bresee JS, Cox NJ. Centers for Disease Control and Prevention. Prevention and control of seasonal influenza with vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep 2009; 58: 1–52 - PubMed
    1. National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention. Use of influenza A (H1N1) 2009 monovalent vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm Rep 2009; 58: 1–8 - PubMed