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Multicenter Study
. 2010 Jul 17;24(11):1778-81.
doi: 10.1097/QAD.0b013e32833a2537.

Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling

Charles S Morrison  1 , Pai-Lien Chen, Cynthia Kwok, Barbra A Richardson, Tsungai Chipato, Roy Mugerwa, Josaphat Byamugisha, Nancy Padian, David D Celentano, Robert A Salata
Affiliations
Multicenter Study

Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling

Charles S Morrison et al. AIDS. .

Abstract

Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.

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