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Comment
. 2010 Jul;78(2):125-7.
doi: 10.1038/ki.2010.80.

A complementary approach to treating antibody-mediated transplant rejection

Peter S Heeger  1
Affiliations
Free article
Comment

A complementary approach to treating antibody-mediated transplant rejection

Peter S Heeger. Kidney Int. 2010 Jul.
Free article

Abstract

Current treatment for antibody-mediated kidney transplant rejection is inadequate. Tillou and colleagues administered recombinant C1 inhibitor to block complement activation to prevent antibody-initiated injury in sensitized baboon recipients of kidney allografts. These early but encouraging results support further testing of the safety and efficacy of complement inhibition as part of a comprehensive strategy to treat this disease, both in animal models and ultimately in humans.

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