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Case Reports
. 2010:2010:161454.
doi: 10.1155/2010/161454. Epub 2010 Jun 2.

Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis

Mahesh Bandara  1 , David B Seder, George Garratty, Regina M Leger, Jonathan B Zuckerman
Affiliations
Case Reports

Piperacillin-induced immune hemolytic anemia in an adult with cystic fibrosis

Mahesh Bandara et al. Case Rep Med. 2010.

Abstract

We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF.

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Figures

Figure 1
Figure 1
Hemoglobin profile over the hospital course. Timing of medical interventions is indicated by symbols (two units of packed red blood cells were given with each transfusion).
See this image and copyright information in PMC

References

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