Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Jun;50(6):376-8.
doi: 10.1136/ard.50.6.376.

Serum selenium concentrations in rheumatoid arthritis

J R O'Dell  1 , S Lemley-Gillespie, W R Palmer, A L Weaver, G F Moore, L W Klassen
Affiliations

Serum selenium concentrations in rheumatoid arthritis

J R O'Dell et al. Ann Rheum Dis. 1991 Jun.

Abstract

Selenium is a trace element and an essential part of the enzyme glutathione peroxidase, which protects cells from oxidative damage. Selenium has been shown to have antiproliferative, anti-inflammatory, antiviral, and immune altering effects. Serum selenium concentrations in 101 patients with seropositive rheumatoid arthritis were found to be significantly lower than those in 29 normal, healthy controls (mean (SD) 148 (42) v 160 (25) micrograms/l) and also lower than those in eight patients with fibrositis (148 (42) v 166 (25) micrograms/l). It is speculated that serum selenium concentrations may modulate the effect of viral or other infections in subjects with the appropriate genetic background and in this way enhance the development or progression of rheumatoid arthritis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Semin Oncol. 1983 Sep;10(3):305-10 - PubMed
    1. Scand J Rheumatol. 1985;14(3):318-9 - PubMed
    1. Science. 1973 Feb 9;179(4073):588-90 - PubMed
    1. Toxicol Appl Pharmacol. 1963 Jul;5:500-6 - PubMed
    1. Scand J Rheumatol. 1978;7(4):237-40 - PubMed