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. 2003 May 15;9(Suppl 1):29-33.
doi: 10.1177/15910199030090S102. Epub 2004 Oct 22.

Hydroxyapatite and bFGF Coating of Detachable Coils for Endovascular Occlusion of Experimental Aneurysm

T Shimozuru  1 , T Kamezawa, J Kuratsu, N Sakai, I Nagata, A Kishida, M Akashi, M Matsusaki
Affiliations

Hydroxyapatite and bFGF Coating of Detachable Coils for Endovascular Occlusion of Experimental Aneurysm

T Shimozuru et al. Interv Neuroradiol. .

Abstract

The purpose of this study was to evaluate the effect of hydroxyapatite (HAp) and fibroblast growth factor-basic (bFGF) coating on Guglielmi detachable coils (GDCs) in an experimental aneurysm model. A total of 18 aneurysms were experimentally made in the common carotid arteries of swine. Embolization was done on these aneurysms using standard GDCs and coated GDCs with HAp (GDC-HAp) and with bFGF (GDC-HAp-bFGF). The animals were then killed 14 days after embolization. The development of tissue scarring and coverage the aneurysm's orifice were evaluated macroscopically. No significant difference of volume ratio of the coils exited in each groups. Macroscopically, covering ratio of fibrous membrane at the neck of aneurysms were 88.3 +/- 14.7% in a group with GDC-HAp-bFGF, while it were 26.7 +/- 15.3% in a group with standard GDC and it was 41.7 +/- 31.7% in a group with GDC-HAp. These results indicated that coating by hydroxyapatite and bFGF might facilitate a wound healing in an experimental aneurysm model.

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Figures

Figure 1
Figure 1
Volume ratio of coils in each groups.
Figure 2
Figure 2
A) Angiograms of experimental aneurysms embolized by GDC-HAp. After tight packing of aneurysms, complete occlusion was recognized 2 weeks later. B) Macroscopic appearances of an aneurysmal orifice. The orifice of aneurysm was covered partially with fibrous tissue.
Figure 3
Figure 3
A) Angiograms of experimental aneurysms embolized by GDC-HAp-bFGF. Complete occlusion was recognized 2 weeks later. B) Macroscopic appearances of an aneurysmal orifice. The orifice of aneurysm was covered completely with thick fibrous tissue.
Figure 4
Figure 4
Covering ratio of orifice of aneurysms in each groups.
See this image and copyright information in PMC

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References

    1. Bavinzski G, Talazoglu V, et al. Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg. 1999;91(2):284–293. - PubMed
    1. Dawson RC, Krisht AF, et al. Treatment of experimental aneurysms using collagen-coated microcoils. Neurosurgery. 1995;36(1):133–139. discussion 139-140. - PubMed
    1. Gruber A, Killer M, et al. Clinical and angiographic results of endosaccular coiling treatment of giant and very large intracranial aneurysms: a 7-year, single-center experience. Neurosurgery. 1999;45(4):793–803. discussion 803-794. - PubMed
    1. Kallmes DF, Helm GA, et al. Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits. Radiology. 1999;213(1):217–222. - PubMed
    1. Kwan ES, Heilman CB, et al. Endovascular packing of carotid bifurcation aneurysm with polyester fiber-coated platinum coils in a rabbit model. Am J Neuroradiol. 1993;14(2):323–333. - PMC - PubMed

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