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. 2010 Jul;63(7):626-9.
doi: 10.1136/jcp.2010.077560.

Positive screening and carrier results for the England-wide universal newborn sickle cell screening programme by ethnicity and area for 2005-07

Allison Streetly  1 , Radoslav Latinovic, Joan Henthorn
Affiliations

Positive screening and carrier results for the England-wide universal newborn sickle cell screening programme by ethnicity and area for 2005-07

Allison Streetly et al. J Clin Pathol. 2010 Jul.

Abstract

Aims: The overall aim of the new national newborn programme is to identify infants at risk of sickle cell disease to allow early detection and to minimise deaths and complications.

Methods: Universal screening for sickle cell disease was introduced in England between September 2003 and July 2006. The 13 newborn laboratories each screen between 25,000 and 110,000 babies a year using the existing dried bloodspot cards. The specified conditions to be screened for include sickle cell anaemia (Hb SS), Hb SC disease, Hb S/beta thalassaemia, Hb S/D(Punjab) and Hb S/O(Arab). Data are reported on screening results by ethnic group and geographical area.

Results: The prevalence of screen positive results across England is 1:2000. There is a 25-fold variation by geographical area. African babies make up 61% of all screen positive results despite representing only 4% of total births. Combined carrier rates vary widely by ethnicity, from 1.85 per 1000 (1:540) in 'White British' to 145 per 1000 (1:7) in 'African' babies. Refusal rates for screening show variation by ethnicity.

Conclusions: These results provide useful information both about the frequency of these conditions and the carrier state and their geographic and ethnic distribution across England. This can be used to refine counselling information and are also useful to target and plan services and public information.

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Carrier rates by ethnic category: April 2005 to March 2007.
Figure 2
Figure 2
Refusal rates per 1000 babies screened: April 2005 to March 2007.
See this image and copyright information in PMC

References

    1. NHS Haemoglobinopathy Screening Programme International workshop report on haemoglobinopathy screening to inform the screening developments in England, 2001. http://sct.screening.nhs.uk/getdata.php?id=11009 (accessed Feb 2010).
    1. NHS Sickle Cell and Thalassaemia Screening Programme Handbook for laboratories. London: NHS Sickle Cell and Thalassaemia Screening Programme, 2009. http://sct.screening.nhs.uk/getdata.php?id=10756 (accessed Feb 2010).
    1. UK Newborn Screening Programme Centre Bloodspot programme. http://newbornbloodspot.screening.nhs.uk (accessed Feb 2010).
    1. Streetly A, Clarke M, Downing M, et al. Implementation of the newborn screening programme for sickle cell disease in England: results for 2003–2005. Journal of Medical Screening 2008;15:9–13 - PubMed
    1. Streetly A, Latinovic R, Hall K, et al. Implementation of universal newborn bloodspot screening for sickle cell disease and other clinically significant haemoglobinopathies in England: screening results for 2005–2007. J Clin Pathol 2009;62:26–30 - PMC - PubMed

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