Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug;10(8):550-60.
doi: 10.1038/nrc2886. Epub 2010 Jul 1.

Human papillomavirus oncoproteins: pathways to transformation

Cary A Moody  1 , Laimonis A Laimins
Affiliations
Review

Human papillomavirus oncoproteins: pathways to transformation

Cary A Moody et al. Nat Rev Cancer. 2010 Aug.

Abstract

An association between human papillomavirus (HPV) infection and the development of cervical cancer was initially reported over 30 years ago, and today there is overwhelming evidence that certain subtypes of HPV are the causative agents of these malignancies. The p53 and retinoblastoma proteins are well-characterized targets of the HPV E6 and E7 oncoproteins, but recent studies have shown that the alteration of additional pathways are equally important for transformation. These additional factors are crucial regulators of cell cycle progression, telomere maintenance, apoptosis and chromosomal stability. Understanding how HPV oncoproteins modify these activities provides novel insights into the basic mechanisms of oncogenesis.

PubMed Disclaimer

References

    1. Virology. 2007 Feb 5;358(1):201-10 - PubMed
    1. PLoS Pathog. 2009 Apr;5(4):e1000397 - PubMed
    1. Virology. 1997 Dec 8;239(1):97-107 - PubMed
    1. Cancer Lett. 2002 Dec 15;188(1-2):15-24 - PubMed
    1. Oncogene. 1994 Apr;9(4):1225-30 - PubMed

Publication types

MeSH terms

Substances