Target identification: HIF2alpha central player in osteoarthritis

Comment

Alexandra Flemming. Nat Rev Drug Discov. 2010 Jul.

. 2010 Jul;9(7):517.

doi: 10.1038/nrd3210.

No abstract available

Comment on

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction.
Yang S, Kim J, Ryu JH, Oh H, Chun CH, Kim BJ, Min BH, Chun JS. Yang S, et al. Nat Med. 2010 Jun;16(6):687-93. doi: 10.1038/nm.2153. Epub 2010 May 23. Nat Med. 2010. PMID: 20495569
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.
Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H. Saito T, et al. Nat Med. 2010 Jun;16(6):678-86. doi: 10.1038/nm.2146. Epub 2010 May 23. Nat Med. 2010. PMID: 20495570