Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Oct;257(10):1612-9.
doi: 10.1007/s00415-010-5641-1. Epub 2010 Jul 1.

Progressive myoclonic epilepsies: review of clinical, molecular and therapeutic aspects

Luis Felipe Mendonça de Siqueira  1
Affiliations
Review

Progressive myoclonic epilepsies: review of clinical, molecular and therapeutic aspects

Luis Felipe Mendonça de Siqueira. J Neurol. 2010 Oct.

Abstract

The progressive myoclonic epilepsies (PME) are a rare group of inherited neurodegenerative diseases with debilitating evolution, resistance to treatment and poor prognosis. However, advances in molecular genetics have enabled better understanding of the pathogenesis of these diseases, bringing hope for improved treatment options in the future. This manuscript is an overview of the clinical and molecular findings in patients with PME. Furthermore, it describes therapeutic approaches that are currently recommended in the literature.

PubMed Disclaimer

References

    1. Am J Hum Genet. 1997 Feb;60(2):342-51 - PubMed
    1. Eur Neurol. 2000;43(2):88-94 - PubMed
    1. Ann Neurol. 1978 Mar;3(3):234-42 - PubMed
    1. Adv Neurol. 2002;89:231-9 - PubMed
    1. Neurology. 1963 Nov;13:919-23 - PubMed

MeSH terms

Substances

LinkOut - more resources