(S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity
- PMID: 205946
Item in Clipboard
(S)-9-(2,3-Dihydroxypropyl)adenine: an aliphatic nucleoside analog with broad-spectrum antiviral activity
Science.
.
Abstract
(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.
Similar articles
-
(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.Science. 1978 May 5;200(4341):563-5. doi: 10.1126/science.200.4341.563. Science. 1978. PMID: 17839440
-
Antiviral activity of aliphatic nucleoside analogues: structure-function relationship.J Med Chem. 1979 May;22(5):510-3. doi: 10.1021/jm00191a010. J Med Chem. 1979. PMID: 222906
-
[Effect of rifampicin on the reproduction of DNA containing viruses in tissue culture cells].Antibiotiki. 1971;16(4):295-8. Antibiotiki. 1971. PMID: 4327917 Russian. No abstract available.
-
Interferon induced inhibition of enveloped viruses.Prog Clin Biol Res. 1985;202:297-305. Prog Clin Biol Res. 1985. PMID: 2421308 Review. No abstract available.
-
Selective virus inhibitors.Microbiologica. 1990 Apr;13(2):165-78. Microbiologica. 1990. PMID: 1693749 Review.
Cited by
-
A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid.Tetrahedron. 2012 May 27;68(21):4003-4012. doi: 10.1016/j.tet.2012.03.066. Epub 2012 Mar 26. Tetrahedron. 2012. PMID: 32287422 Free PMC article.
-
Crystallographic investigation, Hirshfeld surface analysis, NLO characterization and experimental spectral (UV and NMR) studies with DFT probe on(R)-9-(2-hydroxy propyl)adenine.Heliyon. 2021 Apr 29;7(4):e06593. doi: 10.1016/j.heliyon.2021.e06593. eCollection 2021 Apr. Heliyon. 2021. PMID: 33997363 Free PMC article.
-
A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.Expert Opin Investig Drugs. 2012 May;21(5):695-715. doi: 10.1517/13543784.2012.667072. Epub 2012 Mar 7. Expert Opin Investig Drugs. 2012. PMID: 22394224 Free PMC article. Review.
-
Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues.Bioorg Med Chem. 2014 Jul 15;22(14):3629-41. doi: 10.1016/j.bmc.2014.05.020. Epub 2014 May 20. Bioorg Med Chem. 2014. PMID: 24906510 Free PMC article.
-
Developments in antivirals against influenza, smallpox and hemorrhagic fever viruses.Expert Opin Investig Drugs. 2011 Feb;20(2):239-54. doi: 10.1517/13543784.2011.547852. Expert Opin Investig Drugs. 2011. PMID: 21235430 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources