Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug;22(4):475-81.
doi: 10.1016/j.coi.2010.06.003. Epub 2010 Jun 30.

Host response to influenza virus: protection versus immunopathology

J S M Peiris  1 , Kenrie P Y Hui, Hui-Ling Yen
Affiliations
Review

Host response to influenza virus: protection versus immunopathology

J S M Peiris et al. Curr Opin Immunol. 2010 Aug.

Abstract

Host responses play crucial roles in defense against influenza but sometimes these may contribute to immunopathology. Potentially, this may be more important in disease caused by viruses such as avian influenza A H5N1 or the 1918 H1N1 influenza virus rather than with seasonal influenza or pandemic H1N1 2009 (pdmH1N1). Understanding pathogenesis will help develop novel therapeutic options that minimize immunopathology without impairing beneficial host defenses.

PubMed Disclaimer

References

    1. La Gruta NL, Kedzierska K, Stambas J, Doherty PC. A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol. 2007;85:85–92. - PubMed

    1. Peiris JS, Cheung CY, Leung CY, Nicholls JM. Innate immune responses to influenza A H5N1: friend or foe? Trends Immunol. 2009;30:574–584.Review of the beneficial and immunopathological aspects of innate immune responses for H5N1 influenza as well as for seasonal influenza.

    1. Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3:499–522. - PMC - PubMed
    1. Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA. Antibody recognition of a highly conserved influenza virus epitope. Science. 2009;324:246–251. - PMC - PubMed
    1. Hancock K, Veguilla V, Lu X, Zhong W, Butler EN, Sun H, Liu F, Dong L, DeVos JR, Gargiullo PM, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009;361:1945–1952. - PubMed

Publication types

MeSH terms