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Review
. 2010 Jul;15(13-14):570-8.
doi: 10.1016/j.drudis.2010.05.011. Epub 2010 Jun 2.

P2Y nucleotide receptors: promise of therapeutic applications

Kenneth A Jacobson  1 , Jean-Marie Boeynaems
Affiliations
Review

P2Y nucleotide receptors: promise of therapeutic applications

Kenneth A Jacobson et al. Drug Discov Today. 2010 Jul.

Abstract

Extracellular nucleotides, such as ATP and UTP, have distinct signaling roles through a class of G-protein-coupled receptors, termed P2Y. The receptor ligands are typically charged molecules of low bioavailability and stability in vivo. Recent progress in the development of selective agonists and antagonists for P2Y receptors and study of knockout mice have led to new drug concepts based on these receptors. The rapidly accelerating progress in this field has already resulted in drug candidates for cystic fibrosis, dry eye disease and thrombosis. On the horizon are novel treatments for cardiovascular diseases, inflammatory diseases and neurodegeneration.

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Figures

Figure 1
Figure 1
Nucleotides derivatives that have been useful as agonists in the study of the P2Y receptors.
Figure 2
Figure 2
Nucleotides and nonnucleotides that have been useful antagonists in the study of P2Y receptors. A) Antagonists of the Gq-coupled P2Y1-like subfamily. B) Antagonists of the Gi-coupled P2Y12-like subfamily.
Figure 2
Figure 2
Nucleotides and nonnucleotides that have been useful antagonists in the study of P2Y receptors. A) Antagonists of the Gq-coupled P2Y1-like subfamily. B) Antagonists of the Gi-coupled P2Y12-like subfamily.
See this image and copyright information in PMC

References

    1. Idzko M, et al. Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat. Med. 2007;13:913–919. - PubMed
    1. Elliott MR, et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282–286. - PMC - PubMed
    1. Boeynaems JM, et al. Semin. Thromb. Hemost. 2005;31:139–149. - PubMed
    1. Lazarowski ER, et al. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol. Pharmacol. 2003;64:785–795. - PubMed
    1. Abbracchio M, et al. International Union of Pharmacology LVIII. Update on the P2Y G protein-coupled nucleotide receptors: From molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 2006;58:281–341. - PMC - PubMed

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