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. 2010 Jul 1:2010.
doi: 10.1126/science.1190532. Epub 2010 Jul 1.

Genetic signatures of exceptional longevity in humans

Paola Sebastiani  1 , Nadia Solovieff, Annibale Puca, Stephen W Hartley, Efthymia Melista, Stacy Andersen, Daniel A Dworkis, Jemma B Wilk, Richard H Myers, Martin H Steinberg, Monty Montano, Clinton T Baldwin, Thomas T Perls
Affiliations

Genetic signatures of exceptional longevity in humans

Paola Sebastiani et al. Science. .

Retraction in

  • Retraction.
    Sebastiani P, Solovieff N, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Perls TT. Sebastiani P, et al. Science. 2011 Jul 22;333(6041):404. doi: 10.1126/science.333.6041.404-a. Science. 2011. PMID: 21778381 No abstract available.

Expression of concern in

  • Editorial expression of concern.
    Alberts B. Alberts B. Science. 2010 Nov 12;330(6006):912. doi: 10.1126/science.330.6006.912-b. Science. 2010. PMID: 21071647 No abstract available.

Abstract

Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls. Further in silico analysis revealed that 90% of centenarians can be grouped into 19 clusters characterized by different combinations of SNP genotypes-or genetic signatures-of varying predictive value. The different signatures, which attest to the genetic complexity of EL, correlated with differences in the prevalence and age of onset of age-associated diseases (e.g., dementia, hypertension, and cardiovascular disease) and may help dissect this complex phenotype into subphenotypes of healthy aging.

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