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Review
. 2010 Jun;35(2):127-43.

Neuroprotection of sex steroids

M Liu  1 , M H Kelley, P S Herson, P D Hurn
Affiliations
Review

Neuroprotection of sex steroids

M Liu et al. Minerva Endocrinol. 2010 Jun.

Abstract

Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current understanding of neuroprotection by sex steroids, particularly estrogen, androgen, and progesterone, based on both in vitro and in vivo studies. Better understanding of the role of sex steroids under physiological and pathological conditions will help us to develop novel effective therapeutic strategies for brain injury.

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Figures

Figure 1
Figure 1
Mechanisms of neuroprotection by estrogen in the brain.
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References

    1. Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke. 2009;40(4):1082–1090. - PubMed
    1. Turgeon JL, Carr MC, Maki PM, Mendelsohn ME, Wise PM. Complex actions of sex steroids in adipose tissue, the cardiovascular system, and brain: Insights from basic science and clinical studies. Endocr.Rev. 2006;27(6):575–605. - PubMed
    1. Alkayed NJ, Harukuni I, Kimes AS, London ED, Traystman RJ, Hurn PD. Gender-linked brain injury in experimental stroke. Stroke. 1998;29:159–166. - PubMed
    1. Vannucci SJ, Willing LB, Goto S, Alkayed NJ, Brucklacher RM, Wood TL, Towfighi J, Hurn PD, Simpson IA. Experimental stroke in the female diabetic, db/db, mouse. J.Cereb.Blood Flow Metab. 2001;21(0271-678; 1):52–60. - PubMed
    1. Carswell HV, Dominiczak AF, Macrae IM. Estrogen status affects sensitivity to focal cerebral ischemia in stroke-prone spontaneously hypertensive rats. Am.J.Physiol.Heart Circ.Physiol. 2000;278(0363-6135; 1):H290–H294. - PubMed

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