Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Apr;30(2):55-60.
doi: 10.4103/0971-5851.60049.

Chemoradiotherapy in pancreatic carcinoma

Sushmita Pathy  1 , Subhash Chander
Affiliations

Chemoradiotherapy in pancreatic carcinoma

Sushmita Pathy et al. Indian J Med Paediatr Oncol. 2009 Apr.

Abstract

Pancreatic cancer patients present late in their course and surgical resection as a modality of treatment is of limited value. Majority develop loco-regional failure and distant metastasis, therefore, adjuvant therapy comprising of radiotherapy and chemotherapy are useful treatment options to achieve higher loco-regional control. Specialized irradiation techniques like intra-operative radiotherapy that help to increase the total tumor dose have been used, however, controvertible survival benefit was observed. Various studies have shown improved median and overall survival with chemoradiotherapy for advanced unresectable pancreatic carcinoma. The role of new agents such as topoisomerase I inhibitors also needs further clinical investigations.

Keywords: Carcinoma; chemoradiation; pancreas.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest None declared.

Similar articles

See all similar articles

Cited by

References

    1. Cancer Facts and Figures 2006. Atlanta, Ga: American Cancer Society; 2006. American Cancer Society.
    1. An epidemiological study Cancer Incidence. 1992. National Cancer Registry Program. Population based cancer registries 1988-89; pp. 10–4.
    1. Allema JH, Reinders ME, van Gulik TM, Koelemay MJ, van Leeuwen DJ, de Wit LT, et al. Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region. Cancer. 1995;75:2069. - PubMed
    1. Lowy AM, Leach SD. Adjuvant/neoadjuvant chemoradiation for gastric and pancreatric cancer. Oncology. 1999;5:121. - PubMed
    1. Trede M, Schwall G, Saeger HD. Survival after pancreatoduodenectomy: 118 consecutive resections without an operative mortality. Ann Surg. 1990;211:447. - PMC - PubMed

LinkOut - more resources