doi: 10.1016/0005-2736(91)90239-5.
Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells
Affiliations
- PMID: 2059657
- DOI: 10.1016/0005-2736(91)90239-5
Item in Clipboard
Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells
Biochim Biophys Acta.
.
Abstract
Transients of Na+/K+ pump and of Na+/Ca2+ exchange current occur during whole-cell recording from cardiac cells upon quick changes of active Na+ efflux. The transients reflect a temporary loss of control of the subsarcolemmal Na+ concentration. Even in the steady state the control is not complete is certain cells. Quantitative studies on ion transport by whole-cell recording are meaningful only if an adequate control of the submembranal ionic composition is demonstrated.
Similar articles
-
Interaction of the Na+-K+ pump and Na+-Ca2+ exchange via [Na+]i in a restricted space of guinea-pig ventricular cells.J Physiol. 1998 Jun 1;509 ( Pt 2)(Pt 2):457-70. doi: 10.1111/j.1469-7793.1998.457bn.x. J Physiol. 1998. PMID: 9575295 Free PMC article.
-
Stoichiometry of sodium-calcium exchange in cardiac sarcolemmal vesicles. Coupling to the sodium pump.J Biol Chem. 1979 Jul 25;254(14):6232-5. J Biol Chem. 1979. PMID: 447709
-
ATP-dependent Na+ transport in cardiac sarcolemmal vesicles.Biochim Biophys Acta. 1983 Aug 24;733(1):133-41. doi: 10.1016/0005-2736(83)90099-8. Biochim Biophys Acta. 1983. PMID: 6309224
-
Regulation and interaction of intracellular calcium, sodium and hydrogen ions in cardiac muscle.Cardioscience. 1991 Jun;2(2):71-85. Cardioscience. 1991. PMID: 1652299 Review.
-
The Purkinje cell; 2008 style.J Mol Cell Cardiol. 2008 Nov;45(5):617-24. doi: 10.1016/j.yjmcc.2008.08.001. Epub 2008 Aug 8. J Mol Cell Cardiol. 2008. PMID: 18778712 Free PMC article. Review.
Cited by
-
The sodium pump modulates the influence of I(Na) on [Ca2+]i transients in mouse ventricular myocytes.Biophys J. 2001 Mar;80(3):1230-7. doi: 10.1016/S0006-3495(01)76099-7. Biophys J. 2001. PMID: 11222287 Free PMC article.
-
Amino acid substitutions in the rat Na+, K(+)-ATPase alpha 2-subunit alter the cation regulation of pump current expressed in HeLa cells.J Physiol. 1996 Sep 15;495 ( Pt 3)(Pt 3):733-42. doi: 10.1113/jphysiol.1996.sp021629. J Physiol. 1996. PMID: 8887779 Free PMC article.
-
Caffeine-induced immobilization of gating charges in isolated guinea-pig ventricular heart cells.Br J Pharmacol. 2002 Feb;135(3):721-34. doi: 10.1038/sj.bjp.0704520. Br J Pharmacol. 2002. PMID: 11834620 Free PMC article.
-
Na/K pump inactivation, subsarcolemmal Na measurements, and cytoplasmic ion turnover kinetics contradict restricted Na spaces in murine cardiac myocytes.J Gen Physiol. 2017 Jul 3;149(7):727-749. doi: 10.1085/jgp.201711780. Epub 2017 Jun 12. J Gen Physiol. 2017. PMID: 28606910 Free PMC article.
-
Na/K pump-induced [Na](i) gradients in rat ventricular myocytes measured with two-photon microscopy.Biophys J. 2004 Aug;87(2):1360-8. doi: 10.1529/biophysj.103.037895. Biophys J. 2004. PMID: 15298938 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
