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. 1991 Jun 18;1065(2):269-71.
doi: 10.1016/0005-2736(91)90239-5.

Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells

F V Bielen  1 , H G Glitsch, F Verdonck
Affiliations

Changes of the subsarcolemmal Na+ concentration in internally perfused cardiac cells

F V Bielen et al. Biochim Biophys Acta. .

Abstract

Transients of Na+/K+ pump and of Na+/Ca2+ exchange current occur during whole-cell recording from cardiac cells upon quick changes of active Na+ efflux. The transients reflect a temporary loss of control of the subsarcolemmal Na+ concentration. Even in the steady state the control is not complete is certain cells. Quantitative studies on ion transport by whole-cell recording are meaningful only if an adequate control of the submembranal ionic composition is demonstrated.

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