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Review
. 2009 Dec;3(4):327-30.
doi: 10.1007/s12105-009-0147-9. Epub 2009 Nov 15.

Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature

Olga L Bohn  1 , Luis E De las Casas, Marino E Leon
Affiliations
Review

Tumor-to-tumor metastasis: Renal cell carcinoma metastatic to papillary carcinoma of thyroid-report of a case and review of the literature

Olga L Bohn et al. Head Neck Pathol. 2009 Dec.

Abstract

Metastatic disease to thyroid gland is a rare event. Although renal cell carcinoma (RCC) has been reported to metastasize the thyroid gland, metastatic RCC to a thyroid neoplasm is very unusual. We report a case of a 68-year-old man with history of RCC who presented with a 2.5-cm thyroid nodule. Histologic examination demonstrates a renal cell carcinoma metastatic to a papillary carcinoma of the thyroid. The clinicopathologic features of metastatic disease into a thyroid gland neoplasm are shown, and a review of the literature is presented.

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Figures

Fig. 1
Fig. 1
a Papillary thyroid carcinoma: papillary structures lined by cells with longitudinal grooves and intranuclear inclusions (H&E, ×400). b Renal cell carcinoma metastatic to papillary thyroid carcinoma (H&E, ×400). c Thyroglobulin immunostain shows a positive reaction by papillary thyroid carcinoma cells. The renal cell carcinoma cells lack thyroglobulin expression (H&E, ×200). d Metastatic renal cell carcinoma cells are positive for RCC marker, whereas papillary thyroid carcinoma cells are negative (H&E, ×200)
See this image and copyright information in PMC

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