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. 2009 Sep;3(3):225-30.
doi: 10.1007/s12105-009-0128-z. Epub 2009 Jul 21.

What's new in the AFIP fascicle on salivary gland tumors: a few highlights from the 4th Series Atlas

Gary L Ellis  1
Affiliations

What's new in the AFIP fascicle on salivary gland tumors: a few highlights from the 4th Series Atlas

Gary L Ellis. Head Neck Pathol. 2009 Sep.

Abstract

After a 12 year interval from the previous fascicle, a new fascicle on Tumors of the Salivary Glands in the new fourth series of the AFIP Atlas of Tumor Pathology was published in 2008. The data, presentation, illustrations, tables, and physical characteristics of the newest fascicle have been updated and improved. There have only been a few alterations and additions to the classification of tumors and tumor-like non-neoplastic conditions of salivary gland. Three of the most significant are discussed in this paper. Sialoblastoma has been reclassified as malignant; inflammatory pseudotumor has been reclassified as neoplastic and re-identified as inflammatory myofibroblastic tumor; and sclerosing polycystic adenosis is a new entity among tumor-like conditions.

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Figures

Fig. 1
Fig. 1
Sialoblastoma. Nests of basaloid cells have round, vesicular nuclei and poorly demarcated eosinophilic cytoplasm. Collagenous tissue of varying thickness separates tumor aggregates. There are foci of necrosis (top center) with dystrophic calcification
Fig. 2
Fig. 2
Inflammatory myofibroblastic tumor. There are numerous inflammatory cells scattered among a nodular mass of spindled cells, which have a haphazard arrangement. Inset: The inflammatory cell infiltrate is composed of plasma cells, lymphocytes, histiocytes, and eosinophils
Fig. 3
Fig. 3
Inflammatory myofibroblastic tumor. An immunostain for smooth muscle actin reacts with many of the spindled cells
Fig. 4
Fig. 4
Sclerosing polycystic adenosis. There are many cystically dilated ducts as well as enlarged ducts with intraluminal epithelial hyperplasia (adenosis) within a sclerotic collagenous stroma. Note the area of nodular sclerosis on the right and the cystic duct with degenerating enlarged ductal cells with foamy cytoplasm on the left. Inset: acinar-like cells have enlarged eosinophilic cytoplasmic granules
See this image and copyright information in PMC

References

    1. Ellis GL, Auclair PL. Tumors of the salivary glands. atlas of tumor pathology, 3rd series, fascicle 17. Washington DC: Armed Forces Institute of Pathology; 1996.
    1. Ellis GL, Auclair PL. Tumors of the salivary glands. AFIP atlas of tumor pathology, 4th series, fascicle 9. Silver Spring MD: ARP Press; 2008.
    1. Seifert G, Sobin LH. Histological typing of salivary gland tumours. World Health Organization international histological classification of tumours. New York: Springer; 1991.
    1. Williams SB, Ellis GL, Warnock GR. Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol. 2006;10:320–326. doi: 10.1016/j.anndiagpath.2006.02.008. - DOI - PubMed
    1. Barnes L, Eveson J, Reichart P, et al. World health organization classification of tumours. pathology and genetics of head and neck tumours. Lyon: IARC Press; 2005.

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