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. 2010 Oct;203(4):328.e1-5.
doi: 10.1016/j.ajog.2010.05.013. Epub 2010 Jul 3.

Adverse obstetric events are associated with significant risk of cerebral palsy

William M Gilbert  1 , Bryon N Jacoby, Guibo Xing, Beate Danielsen, Lloyd H Smith
Affiliations

Adverse obstetric events are associated with significant risk of cerebral palsy

William M Gilbert et al. Am J Obstet Gynecol. 2010 Oct.

Abstract

Objective: To examine adverse birth events on the development of cerebral palsy in California.

Study design: A retrospective population-based study of children with cerebral palsy (as of Nov. 30, 2006), matched to their maternal/infant delivery records (Jan. 1, 1991 to Dec. 31, 2001) was performed. Demographic data and intrapartum events were examined. Six adverse birth-related events were chosen. Children without cerebral palsy were controls.

Results: There were 7242 children who had cerebral palsy (59% term) and 31.3% had 1 or more of the 6 adverse intrapartum events (12.9% in controls P < .0001). This held for both term (28.3% vs 12.7% controls) and preterm (36.8% vs 15.9%, controls) neonates (both P < .0001). Maternal (15.1% vs 6.6%) and neonatal (0.9% vs 0.1%) infection were increased in cerebral palsy cases (P < .0001).

Conclusion: Almost one-third of children with cerebral palsy had at least 1 adverse birth-related event. Higher rates in the preterm group may partially explain the higher rates of cerebral palsy in this group.

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