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Multicenter Study
. 2010 Nov;157(5):726-32.e1.
doi: 10.1016/j.jpeds.2010.05.026.

Extreme premature birth is not associated with impaired development of brain microstructure

Sonia L Bonifacio  1 , Hannah C Glass, Vann Chau, Jeffrey I Berman, Duan Xu, Rollin Brant, A James Barkovich, Kenneth J Poskitt, Steven P Miller, Donna M Ferriero
Affiliations
Multicenter Study

Extreme premature birth is not associated with impaired development of brain microstructure

Sonia L Bonifacio et al. J Pediatr. 2010 Nov.

Abstract

Objective: To assess whether birth at <26 weeks gestation is an important predictor of brain microstructure maturation as determined by using diffusion tensor imaging.

Study design: We performed serial magnetic resonance imaging and diffusion tensor imaging in 176 infants born at <33 weeks gestation. Diffusion parameters were calculated for white and gray matter regions. Linear regression for repeated measures was used to assess the effect of extremely premature birth on brain maturation.

Results: In white matter, fractional anisotropy increased by 0.008 per week (95% CI, 0.007-0.009; P < .0001) and mean diffusivity decreased by 0.021 mm(2)/sec per week, (95% CI, -0.24-0.018; P < .0001). Birth at <26 weeks was associated with lower white matter fractional anisotropy (-0.01; 95% CI, -0.018-0.003; P = .008), but this effect was eliminated when co-morbid conditions were added to the model. Moderate-severe brain injury was associated with decreased mean white matter fractional anisotropy (-0.012; 95% CI, -0.02-0.004; P = .002).

Conclusion: Brain microstructure maturation as measured serially in premature infants is independent of extremely premature birth. Brain injury and co-morbid conditions may be the important determinants of microstructure maturation.

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Figures

Figure
Figure. Regions of Interest
These are the unsmoothed ADC maps that demonstrate the regions of interest in which mean diffusivity and fractional anisotropy were measured in white and gray matter regions. This infant was born at 24.5 weeks gestation and imaged at 29 weeks.
See this image and copyright information in PMC

References

    1. Wilson-Costello D, Friedman H, Minich N, Fanaroff AA, Hack M. Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s. Pediatrics. 2005 Apr;115:997–1003. - PubMed
    1. Eichenwald EC, Stark AR. Management and outcomes of very low birth weight. N Engl J Med. 2008 Apr 17;358:1700–1711. - PubMed
    1. Hack M, Fanaroff AA. Outcomes of children of extremely low birthweight and gestational age in the 1990s. Semin Neonatol. 2000 May;5:89–106. - PubMed
    1. Wood NS, Marlow N, Costeloe K, Gibson AT, Wilkinson AR. Neurologic and developmental disability after extremely preterm birth. EPICure Study Group. N Engl J Med. 2000 Aug 10;343:378–384. - PubMed
    1. Wood NS, Costeloe K, Gibson AT, Hennessy EM, Marlow N, Wilkinson AR. The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth. Arch Dis Child Fetal Neonatal Ed. 2005 Mar;90:F134–F140. - PMC - PubMed

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