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. 2010 Aug 1;20(15):4550-4.
doi: 10.1016/j.bmcl.2010.06.019. Epub 2010 Jun 17.

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

Yibin Xiang  1 , Bradford Hirth, John L Kane Jr, Junkai Liao, Kevin D Noson, Christopher Yee, Gary Asmussen, Maria Fitzgerald, Christine Klaus, Michael Booker
Affiliations

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

Yibin Xiang et al. Bioorg Med Chem Lett. .

Abstract

Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study.

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