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. 2011 Apr;21(4):237-42.
doi: 10.1097/FPC.0b013e32833c6107.

PharmGKB summary: fluoropyrimidine pathways

Caroline F Thorn  1 , Sharon Marsh, Michelle Whirl Carrillo, Howard L McLeod, Teri E Klein, Russ B Altman
Affiliations

PharmGKB summary: fluoropyrimidine pathways

Caroline F Thorn et al. Pharmacogenet Genomics. 2011 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Graphic representation of the candidate genes involved in fluoropyrimidine pharmacokinetics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/do/serve?objId=PA150653776&objCls=Pathway. 5′-dFCR, 5′-deoxy-5-fluorocytidine; 5′-dFUR, 5′-deoxy-5-fluorouridine; 5-FU, 5-fluorouracil; ABCC, ATP-binding cassette, sub-family C; CDA, cytidine deaminase; CES, carboxylesterase; DHFU, dihydrofluorouracil; DPYD, dihydropyrimidine dehydrogenase’; DPYS, dihydropyrimidinease; FBAL, fluoro-β-alanine; FdUDP, fluorodeoxyuridine diphosphate; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluoro-deoxyuridine triphosphate; FUDP, fluorouridine diphosphate; FUDR, fluorodeoxyuridine; FUMP, fluorouridine monophosphate; FUPA, fluoro-β-ureidopropionate; FUR, fluroridine; FUTP, fluorouridine triphosphate; PD, pharmacodynamic; PPAT, phosphoribosyl pyrophosphate amidotransferase; RRM, ribonucleotide reductase M; TK1, thymidine kinase 1; Tp53, tumor protein p53; TYMP, thymidylate phosphorylase; TYMS, thymidylate synthase; UCK, uridine-cytidine kinase; UMPS, uridine monophosphate synthase; UPB1, β-ureidopropionase 1; UPP, uridine phosphorylase.
Fig. 2
Fig. 2
Graphic representation of the candidate genes involved in fluoropyrimidine pharmacodynamics. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/search/pathway/5fu/5fu-pd.jsp. DHF, dihydrofolate; DHFR, dihydrofolate reductase; dTMP, deoxythymidine monophosphate; dUMP, deoxyuridine monophosphate; ERCC, excision repair cross complementing; FdUMP, fluorodeoxyuridine monophosphate; FdUTP, fluoro-deoxyuridine triphosphate; FPGS, folylpolyglutamate synthase; FUTP, fluorouridine triphosphate; GGH, Gammaglutamyl hydrolase; MTHFR, methylenetetrahydrofolate reductase; PK, pharmacokinetics; SMUG1, Single-strand selective monofunctional uracil DNA glycosylase 1; TDG, thymidine DNA glycosylase; THF, 5,10-methylene tetrahydrofolate; TYMS, thymidylate synthase.
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References

    1. Diasio RB, Harris BE. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet. 1989;16:215–237. - PubMed
    1. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3:330–338. - PubMed
    1. Hwang JJ, Marshall JL. Capecitabine: fulfilling the promise of oral chemotherapy. Expert Opin Pharmacother. 2002;3:733–743. - PubMed
    1. Miwa M, Ura M, Nishida M, Sawada N, Ishikawa T, Mori K, et al. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer. 1998;34:1274–1281. - PubMed
    1. Yen-Revollo JL, Goldberg RM, McLeod HL. Can inhibiting dihydropyrimidine dehydrogenase limit hand-foot syndrome caused by fluoropyrimidines? Clin Cancer Res. 2008;14:8–13. - PubMed

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