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Clinical Trial
. 2010 Jun;64(3):268-73.
doi: 10.1111/j.1440-1819.2010.02091.x.

Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda  1 , Tatsuyo Suzuki, Taro Kishi, Yoshio Yamanouchi, Kazunori Umeda, Hiroshi Haitoh, Shuji Hashimoto, Norio Ozaki, Nakao Iwata
Affiliations
Free article
Clinical Trial

Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda et al. Psychiatry Clin Neurosci. 2010 Jun.
Free article

Abstract

Aims: The aim of this study was to analyze the relation between treatment response and the duration of untreated illness (DUI) in 133 outpatients with the first major depressive disorder (MDD) episode.

Methods: A logistic regression was performed with DUI, sex, age at onset, and score for 17 items on the Hamilton Depression Rating Scale at the time of start of fluvoxamine treatment as the explanatory variables, and the response and the remission as the outcome variables.

Results: Regression analysis showed significant association between the response and DUI (P < 0.0001), and between the remission and DUI (P < 0.0001), respectively. The remission rate gradually decreased with longer DUI.

Conclusion: Early treatment of first depressive episodes is important because a shorter DUI implied better remission outcomes.

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