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. 2010 Jul 9;142(1):9-14.
doi: 10.1016/j.cell.2010.06.029.

Metabolic networks of longevity

Riekelt H Houtkooper  1 , Robert W Williams, Johan Auwerx
Affiliations

Metabolic networks of longevity

Riekelt H Houtkooper et al. Cell. .

Abstract

Molecular and cellular networks implicated in aging depend on a multitude of proteins that collectively mount adaptive and contingent metabolic responses to environmental challenges. Here, we discuss the intimate links between metabolic regulation and longevity and outline new approaches for analyzing and manipulating such links to promote human health span.

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Figures

Figure 1
Figure 1. A metabolic network of aging
A simplified scheme for metabolic proteins that are involved in longevity. There are complex interactions among individual metabolic signaling pathways, such as the insulin/IGF1, TOR, AMPK, sirtuin and FOXO pathways. These interactions impact healthspan and longevity. For instance, the TOR pathway, which is activated in situations of nutrient excess, is not only linked to other nutrient-responsive pathways, such as the insulin/IGF1 pathway, but also to the CR-induced pathway involving AMPK and Foxa activation. Longevity promoting proteins are in green, proteins that when mutated increase longevity are in red, other proteins are indicated in blue; mammalian protein names are used.
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