doi: 10.1016/j.phymed.2010.04.002.
Epub 2010 Jun 1.
Anticonvulsant activity of embelin isolated from Embelia ribes
Affiliations
- PMID: 20605710
- DOI: 10.1016/j.phymed.2010.04.002
Item in Clipboard
Anticonvulsant activity of embelin isolated from Embelia ribes
Phytomedicine.
.
Abstract
Anticonvulsant activity of embelin (2.5, 5 and 10mg/kg, i.p.) was studied. It showed a significant inhibition of the seizures induced by electroshock and pentylenetetrazole in a dose dependent manner and the activity was comparable to phenytoin and diazepam. Significant decrease in locomotion revealing its CNS depressant activity was observed. The findings suggest that embelin possess anticonvulsant activity against both grand mal and petit mal epilepsy.
2010 Elsevier GmbH. All rights reserved.
Similar articles
-
Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.J Ethnopharmacol. 2007 Feb 12;109(3):529-34. doi: 10.1016/j.jep.2006.09.003. Epub 2006 Sep 8. J Ethnopharmacol. 2007. PMID: 17034970
-
Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice.Phytomedicine. 2004 Jan;11(1):56-64. doi: 10.1078/0944-7113-00376. Phytomedicine. 2004. PMID: 14971722
-
An experimental evaluation of anticonvulsant activity of Vitex-negundo.Indian J Physiol Pharmacol. 2005 Apr;49(2):199-205. Indian J Physiol Pharmacol. 2005. PMID: 16170989
-
Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.Future Med Chem. 2018 Apr 1;10(8):961-976. doi: 10.4155/fmc-2017-0198. Epub 2018 Apr 5. Future Med Chem. 2018. PMID: 29620447 Review.
-
Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives.Curr Med Chem. 2017;24(18):1998-2009. doi: 10.2174/0929867324666170116125731. Curr Med Chem. 2017. PMID: 28093981 Review.
Cited by
-
Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats.Mol Neurobiol. 2017 Nov;54(9):6670-6680. doi: 10.1007/s12035-016-0182-y. Epub 2016 Oct 15. Mol Neurobiol. 2017. PMID: 27744573
-
Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats.Indian J Pharmacol. 2011 Nov;43(6):699-702. doi: 10.4103/0253-7613.89829. Indian J Pharmacol. 2011. PMID: 22144777 Free PMC article.
-
Embelin, a Potent Molecule for Alzheimer's Disease: A Proof of Concept From Blood-Brain Barrier Permeability, Acetylcholinesterase Inhibition and Molecular Docking Studies.Front Neurosci. 2019 May 16;13:495. doi: 10.3389/fnins.2019.00495. eCollection 2019. Front Neurosci. 2019. PMID: 31156375 Free PMC article.
-
Assessment of luteolin isolated from Eclipta alba leaves in animal models of epilepsy.Pharm Biol. 2017 Dec;55(1):264-268. doi: 10.1080/13880209.2016.1260597. Pharm Biol. 2017. PMID: 27927066 Free PMC article.
-
Passiflora caerulea L. fruit extract and its metabolites ameliorate epileptic seizure, cognitive deficit and oxidative stress in pilocarpine-induced epileptic mice.Metab Brain Dis. 2020 Jan;35(1):159-173. doi: 10.1007/s11011-019-00501-5. Epub 2019 Nov 14. Metab Brain Dis. 2020. PMID: 31728889
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
