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. 1991 Jun 17;284(1):120-2.
doi: 10.1016/0014-5793(91)80776-y.

Down-regulation of a kinase defective PKC-alpha

C Pears  1 , P J Parker
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Free article

Down-regulation of a kinase defective PKC-alpha

C Pears et al. FEBS Lett. .
Free article

Abstract

A kinase defective mutant of PKC-alpha down-regulates in response to phorbol esters as effectively as the wild-type protein when introduced into COS-1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down-regulation.

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