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Comment
. 2010 Jul 7;29(13):2099-100.
doi: 10.1038/emboj.2010.132.

Receptor endocytosis: Frizzled joins the ubiquitin club

Ken M Cadigan  1
Affiliations
Comment

Receptor endocytosis: Frizzled joins the ubiquitin club

Ken M Cadigan. EMBO J. .
No abstract available

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
Mono-ubiquitylation of the Wnt receptor Fz determines the responsiveness of cells to Wnt stimulation. (A) The Fz ubiquitylation cycle. Mono-ubiquitin is symbolized by the red pentagons. After Fz ubiquitylation, UBPY promotes recycling of Fz by catalyzing its deubiquitylation. See text for further explanation. (B) Wnt/β-catenin signalling in cells depleted of UBPY. When UBPY activity is low, there is less cell surface Fz, resulting in limited inhibition of the β-catenin destruction complex by the Wnt activated Fz-LRP5/6/Arr receptor complex. The destruction complex continues to phosphorylate most of the cytosolic β-catenin, targeting it for degradation. (C) When UBPY activity is high, more Fz is present on the surface, resulting in stronger destruction complex inhibition, less β-catenin phosphorylation/degradation and thus higher signalling levels. This model assumes that Fz is the rate-limiting factor in the Wnt receptor complex, with Arr present in excess. See additional references for more information on the mechanism of Wnt/β-catenin signalling (Cadigan and Peifer, 2009; MacDonald et al, 2009).
See this image and copyright information in PMC

Comment on

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