Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;42(1):50-2.
doi: 10.4103/0253-7613.62407.

Imatinib-induced pancreatitis

Mahesh R Varma  1 , Shibi Mathew, Devadas Krishnadas, K R Vinayakumar
Affiliations

Imatinib-induced pancreatitis

Mahesh R Varma et al. Indian J Pharmacol. 2010 Feb.

Abstract

Drug-induced pancreatitis is a rare but serious complication of many drugs, some of which have been well documented. Here we present a case of a middle-aged man with chronic myeloid leukemia who developed acute pancreatitis after being initiated on imatinib mesylate. The case history, the pharmacodynamics, uses, and adverse effects of imatinib mesylate are discussed in detail.

Keywords: Acute pancreatitis; chronic myeloid leukemia; imatinib mesylate.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Contrast enhanced CT scan of the pancreas showing cystic lesions in the body and tail of pancreas. Splenomegaly is also noted.
Figure 2
Figure 2
CT scan of the pancreas showing pseudocysts in the body and tail.
Figure 3
Figure 3
MRCP showing pancreaticopleural fistula with pleural effusion.
Figure 4
Figure 4
MRCP image showing a connection with pancreatic duct and the pleural space.
See this image and copyright information in PMC

References

    1. Forsmark CE, Baillie J AGA Institute Clinical Practice and Economics Committee, AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology. 2007;132:2022–44. - PubMed
    1. Levy P, Mathurin P, Roqueplo A, Rueff B, Bernades P. A multidimensional case-control study of dietary, alcohol, and tobacco habits in alcoholic men with chronic pancreatitis. Pancreas. 1995;10:231–8. - PubMed
    1. Naranjo C, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239–45. - PubMed
    1. Yanada M, Takeuchi J, Sugiura I, Akiyama H, Usui N, Yagasaki F, et al. High complete remission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia: A phase II study by the Japan Adult Leukemia Study Group. J Clin Oncol. 2006;24:460–6. - PubMed
    1. Greenberger NJ, Toskes PP. Acute and chronic pancreatitis. Harrison's Online. Available from: http://www.accessmedicine.com. [accessed on 2006 May 31] - PubMed