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Case Reports
. 2010 Jan;3(1):26-8.
doi: 10.4103/0974-620X.60018.

Topiramate-induced angle closure with acute myopia, macular striae

S Natesh  1 , S K Rajashekhara, A S D Rao, B Shetty
Affiliations
Case Reports

Topiramate-induced angle closure with acute myopia, macular striae

S Natesh et al. Oman J Ophthalmol. 2010 Jan.

Abstract

Topiramate is a sulfamate-substituted monosaccharide used in the treatment of seizures, and prophylaxis of migraine. A number of ocular side-effects have been described with use of topiramate, like bilateral angle closure, acute myopia and macular striae. Ultrasound biomicroscopy (UBM) clinches the diagnosis after ruling out other causes of shallow anterior chamber. Previous studies have not demonstrated internal limiting membrane folds presenting as macular striae. We report a case of topiramate-induced acute myopia with angle closure and macular striae in a young adult. This is the first report wherein striae formation after low doses of topiramate and their resolution have been documented by Optical Coherence Tomography (OCT).

Keywords: Topiramate; macular striae; optical coherence tomography.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Scanning laser ophthalmoscope and optical coherence tomography images of the fundus OS showing (a) internal limiting membrane folds at the macula and (b) resolution of internal limiting membrane folds after cessation of topiramate
Figure 2
Figure 2
Ultrasound Biomicroscopy picture of the anterior segment OS showing the; (a) iris; (b) anteriorly rotated ciliary body and; (c) supraciliary effusion. Note the angle closure
See this image and copyright information in PMC

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