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. 2010 Jan;3(1):11-4.
doi: 10.4103/0974-1208.63115.

Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats

Ea Ashamu  1 , Eo Salawu, Oo Oyewo, Aw Alhassan, Oa Alamu, Aa Adegoke
Affiliations

Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats

Ea Ashamu et al. J Hum Reprod Sci. 2010 Jan.

Abstract

Aims: This study investigates the efficacy of ethanolic extract of Sesamum indicum (EES), vitamin C (VC), and EES + VC in promoting fertility and finding a possible link between their profertility effects and their antioxidant activities.

Materials and methods: Forty adult male Wistar rats [Body weight (BW) 186.56 +/- 0.465 g] were randomly analyzed into four groups of ten rats each: Control, EES(G) (EES only), VC(G) (vitamin C only), and EES + VC(G) (EES in conjunction with vitamin C). Control was given 5 ml/kg BW/day of normal saline orally; EES(G) was administered 0.3 g/kg BW/day of EES; VC(G) was administered 15 mg/kg BW/ day of VC; while EES + VC(G) was administered both 0.3 g/kg BW/day of EES and 15 mg/kg BW/day of VC. All treatments were for 10 weeks.

Statistical analysis used: Independent-sample T test was used to analyze the obtained results.

Results: The results obtained showed that EES, VC, and more importantly EES + VC are capable of significantly increasing BW gain, seminal parameters, testosterone level, and body antioxidant activities.

Conclusions: These findings lead to the conclusion that EES + VC as well as ESS and VC promote fertility due to both their testosterone-increasing effects and their antioxidant effects.

Keywords: Antioxidant; Sesamum indicum; fertility; sperm count; vitamin C.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Peter JH. The role of plants in traditional medicine and current therapy. J Altern Complement Med. 1995;1:131–143. - PubMed
    1. Asenso-Okyere WK, Anum A, Osei-Akoto I, Adukonu A. Cost recovery in Ghana: Are there any changes in health care seeking behaviour? Health Policy Plan. 1998;13:181–8. - PubMed
    1. Oluyemi KA, Jimoh OR, Adesanya OA, Omotuyi IO, Josiah SJ, Oyesola TO. Effects of crude ethanolic extract of Garcinia cambogia on the reproductive system of male wistar rats (Rattus Novergicus) Afr J Biotech. 2007;6:1236–8.
    1. Adesanya OA, Oluyemi KA, Ofusori DO, Omotuyi IU, Okwuonu CO, Ukwenya VA. Micromorphometric and stereological effects of ethanolic extracts of Garcinia cambogia seeds on the testes and epididymides of Adult Wistar Rats. Int J Alt Med. 2007;5:32–7.
    1. Kizhiyedathu PS, Ananthasankaran J, Chami A. In vitro studies on antioxidant activity of lignans isolated from sesame cake extract. J Sci of Food and Agri. 2005;85:1779–83.

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