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. 1991 Apr 15;63(2-3):247-50.
doi: 10.1016/0378-1097(91)90093-p.

Cloning of nocardioform DNA conferring the ability to inactivate rifampicin

S J Andersen  1 , E R Dabbs
Affiliations

Cloning of nocardioform DNA conferring the ability to inactivate rifampicin

S J Andersen et al. FEMS Microbiol Lett. .

Abstract

A novel mechanism of resistance to rifampicin has recently been reported in which this antibiotic is inactivated. Here we describe the cloning of DNA from a nocardiofrom strain conferring this ability to inactivate rifampicin. Cloning was on the basis of complementation, as an increased resistance to the antibiotic. The genetic information was on a 8.3-kb BglII fragment.

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