[Tolerance of ibuprofen. Controlled drug monitoring for the detection of rare side effects]

Abstract

In an observational study, 6,299 patients suffering from arthrosis and other rheumatic diseases were treated by 1,258 physicians with coated tablets containing 400 mg or 600 mg ibuprofen (Ibuprofen Klinge 400/600) with a view to establish tolerance and the incidence of rare side effects. The data of a random sample of 500 patients revealed, depending upon the nature of the disease presenting, good to very good improvement of pain, swelling and impaired mobility. Only 3% of the patients reported side effects, 0.3% of which were allergic in nature. Only 0.8% of the patients terminated treatment. The care-providing physicians assessed the results as very good or good in 93.3% for efficacy, and 96.8% for tolerance.