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Comment
. 2010 Jul 13;18(1):3-4.
doi: 10.1016/j.ccr.2010.06.007.

HIF-1alpha partners with FoxA2, a neuroendocrine-specific transcription factor, to promote tumorigenesis

T S Karin Eisinger-Mathason  1 , M Celeste Simon
Affiliations
Comment

HIF-1alpha partners with FoxA2, a neuroendocrine-specific transcription factor, to promote tumorigenesis

T S Karin Eisinger-Mathason et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Qi et al. report a novel mechanism by which HIF-1alpha synergizes with a tissue-specific transcription factor, FoxA2, to promote a transcriptional program that supports prostate tumor formation and progression.

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Figures

Figure 1
Figure 1. The effects of Siah2 inhibition and HIF stabilization on prostate cancer formation
Deletion of Siah2 results in decreased HIFα and HIF target (Hes6, Sox9, Jmjd1a) expression in the TRAMP model of prostate cancer. HIF1αsynergizes with the neuroendocrine specific transcription factor, FoxA2, to regulate transcription of these genes and drive both tumorigenesis and the neuroendocrine phenotype in a hypoxia-dependent-manner.
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