Comment
doi: 10.1016/j.ccr.2010.06.006.
The molecular biology of myeloproliferative disorders
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- PMID: 20609348
- DOI: 10.1016/j.ccr.2010.06.006
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Comment
The molecular biology of myeloproliferative disorders
Cancer Cell.
.
Free article
Abstract
The myeloproliferative disorders (MPDs) are a spectrum of clonal disorders of the hematopoietic system. The discovery of activating mutations of the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and primary myelofibrosis has lead to in vitro and animal model studies that promise to lead to therapeutic advances.
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Comment on
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Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.Cancer Cell. 2010 Jun 15;17(6):584-96. doi: 10.1016/j.ccr.2010.05.015. Cancer Cell. 2010. PMID: 20541703 Free PMC article.
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