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. 2007 Dec;1(2):141-5.
doi: 10.1007/s12105-007-0020-7. Epub 2007 Dec 1.

An update on Epstein-Barr virus and nasopharyngeal carcinogenesis

Bayardo Perez-Ordoñez  1
Affiliations

An update on Epstein-Barr virus and nasopharyngeal carcinogenesis

Bayardo Perez-Ordoñez. Head Neck Pathol. 2007 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Patient with T3N1M0 nasopharyngeal carcinoma with 8,667 EBV-DNA copies/ml before combined chemoradiation. The EBV-DNA levels dropped to 238 copies/ml after completion of therapy but increased to 17,333 copies/ml after the development of pulmonary metastases. (Courtesy of Dr. Suzanne Kamel-Reid)
Fig. 2
Fig. 2
Nonkeratinizing nasopharyngeal carcinoma in-situ with strong EBERs expression by ISH (inset)
Fig. 3
Fig. 3
Surgical pathology of nasopharyngeal carcinoma. Nonkeratinizing carcinoma, differentiated-type composed of intermediate size cells with well defined eosinophilic cytoplasm and oval nuclei lacking prominent nucleoli. This case shows formation of a whorl (A). Nonkeratinizing carcinoma, undifferentiated-type is composed of large cells with amphophilic cytoplasm showing vesicular chromatin and prominent nucleoli (B). Keratinizing squamous carcinoma accompanied by carcinoma in-situ (C). Basaloid squamous cell carcinoma showing composed of small cells with peripheral palisading and formation of eosinophilic cylinders of basal lamina material (D)
Fig. 4
Fig. 4
Proposed model of nasopharyngeal carcinogenesis with progressive accumulation of genetic and epigenetic abnormalities and corresponding histopathologic and clinical features
See this image and copyright information in PMC

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