Comment
doi: 10.1073/pnas.1007331107.
Epub 2010 Jun 28.
One-way ticket to the cell pole: plasmid transport by the prokaryotic tubulin homolog TubZ
Affiliations
- PMID: 20616084
- PMCID: PMC2901473
- DOI: 10.1073/pnas.1007331107
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Comment
One-way ticket to the cell pole: plasmid transport by the prokaryotic tubulin homolog TubZ
Proc Natl Acad Sci U S A.
.
No abstract available
Conflict of interest statement
The author declares no conflict of interest.
Figures
Model for TubRZ-mediated segregation of pBtoxis. Snapshots of three successive stages of the process are shown. The TubR-pBtoxis complex associates with the treadmilling TubZ polymer via the interaction of TubR with the flexible C terminus of TubZ subunits. TubR bound to its cargo is handed over to successive TubZ subunits of the polymer in the (+) elongating direction. The bending of the TubZ filament at the cell pole exerts strain on the bound cargo, causing detachment of TubR-pBtoxis.
Comment on
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Plasmid protein TubR uses a distinct mode of HTH-DNA binding and recruits the prokaryotic tubulin homolog TubZ to effect DNA partition.Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11763-8. doi: 10.1073/pnas.1003817107. Epub 2010 Jun 4. Proc Natl Acad Sci U S A. 2010. PMID: 20534443 Free PMC article.
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