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Multicenter Study
. 2010 Jul 8:341:c3324.
doi: 10.1136/bmj.c3324.

Functional decline after incident wrist fractures--Study of Osteoporotic Fractures: prospective cohort study

Beatrice J Edwards  1 , Jing Song, Dorothy D Dunlop, Howard A Fink, Jane A Cauley
Affiliations
Multicenter Study

Functional decline after incident wrist fractures--Study of Osteoporotic Fractures: prospective cohort study

Beatrice J Edwards et al. BMJ. .

Abstract

Objective: To study the effect of an incident wrist fracture on functional status in women enrolled in the Study of Osteoporotic Fractures.

Design: Prospective cohort study.

Setting: Baltimore, Minneapolis, Portland, and the Monongahela valley in Pennsylvania, USA PARTICIPANTS: 6107 women aged 65 years and older without previous wrist or hip fracture recruited from the community between September 1986 and October 1988.

Main outcome measure: Clinically important functional decline, defined as a functional deterioration of 5 points in five activities of daily living each scored from 0 to 3 (equivalent to one standard deviation decrease in functional ability).

Results: Over a mean follow-up of 7.6 years, 268 women had an incident wrist fracture and 41 (15%) of these developed clinically important functional decline. Compared with women without wrist fractures, those with incident wrist fractures had greater annual functional decline after adjustment for age, body mass index, and health status. Occurrence of a wrist fracture increased the odds of having a clinically important functional decline by 48% (odds ratio 1.48, 95% confidence interval 1.04 to 2.12), even after adjustment for age, body mass index, health status, baseline functional status, lifestyle factors, comorbidities, and neuromuscular function.

Conclusions: Wrist fractures contribute to clinically important functional decline in older women.

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Conflict of interest statement

Competing interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare (1) no support from any company for the submitted work; (2) no relationships with any companies that might have an interest in the submitted work in the previous 3 years; (3) their spouses, partners, or children have no financial relationships that may be relevant to the submitted work; and (4) no non-financial interests that may be relevant to the submitted work.

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