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. 2010 Jul 9;329(5988):150-1.
doi: 10.1126/science.1193995.

Transcription. Repressive transcription

Matthew G Guenther  1 , Richard A Young
Affiliations

Transcription. Repressive transcription

Matthew G Guenther et al. Science. .
No abstract available

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Figures

None
Transcription and chromatin dynamics
(A) Transcription initiation, recruitment of TrxG complexes, which catalyze H3K4me3 (blue dot), and production of CG-rich RNAs occur in the promoter regions of most genes. The CG-rich RNAs often form structures that recruit PcG complexes, which catalyze H3K27me3 (red dot). (B) PcG complexes can spread beyond the nucleation site to establish repression. (C) At genes where the transcription apparatus is continuously recruited by activating transcription factors, activities associated with TrxG proteins predominate, reducing PcG complexes and their associated histone modifications. Pol II, polymerase II.
See this image and copyright information in PMC

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