Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug;9(8):615-27.
doi: 10.1038/nrd2591. Epub 2010 Jul 9.

Strategies in the design of nanoparticles for therapeutic applications

Robby A Petros  1 , Joseph M DeSimone
Affiliations
Review

Strategies in the design of nanoparticles for therapeutic applications

Robby A Petros et al. Nat Rev Drug Discov. 2010 Aug.

Abstract

Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases; for example, by allowing the targeted delivery of a drug to particular subsets of cells. However, so far, such nanoparticles have not proved capable of surmounting all of the biological barriers required to achieve this goal. Nevertheless, advances in nanoparticle engineering, as well as advances in understanding the importance of nanoparticle characteristics such as size, shape and surface properties for biological interactions, are creating new opportunities for the development of nanoparticles for therapeutic applications. This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.

PubMed Disclaimer

References

    1. Cell Mol Life Sci. 2009 Sep;66(17):2873-96 - PubMed
    1. Crit Rev Ther Drug Carrier Syst. 1994;11(1):31-59 - PubMed
    1. J Nucl Med. 1972 Jul;13(7):498-503 - PubMed
    1. Pharm Res. 2009 Jan;26(1):244-9 - PubMed
    1. Pharm Res. 2009 Jan;26(1):235-43 - PubMed

Publication types

Substances

LinkOut - more resources