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Review
. 2010 Apr;7(4):1760-72.
doi: 10.3390/ijerph7041760. Epub 2010 Apr 16.

Maternal diet, behaviour and offspring skeletal health

Laura R Goodfellow  1 , Susannah Earl, Cyrus Cooper, Nicholas C Harvey
Affiliations
Review

Maternal diet, behaviour and offspring skeletal health

Laura R Goodfellow et al. Int J Environ Res Public Health. 2010 Apr.

Abstract

Osteoporotic fracture has a major impact upon health, both in terms of acute and long term disability and economic cost. Peak bone mass, achieved in early adulthood, is a major determinant of osteoporosis risk in later life. Poor early growth predicts reduced bone mass, and so risk of fracture in later life. Maternal lifestyle, body build and 25(OH) vitamin D status predict offspring bone mass. Recent work has suggested epigenetic mechanisms as key to these observations. This review will explore the role of the early environment in determining later osteoporotic fracture risk.

Keywords: bone mass; early life origins; epigenetic; fetus; fracture; neonate; osteoporosis; vitamin D.

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