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Multicenter Study
. 2010 Jun;14(6):418-26.
doi: 10.1007/s12603-010-0031-z.

Prediction of fat-free mass by bioelectrical impedance analysis in older adults from developing countries: a cross-validation study using the deuterium dilution method

H Aleman-Mateo  1 , E Rush, J Esparza-Romero, E Ferriolli, M Ramirez-Zea, A Bour, G Yuchingtat, R Ndour, N Mokhtar, M E Valencia, D A Schoeller
Affiliations
Multicenter Study

Prediction of fat-free mass by bioelectrical impedance analysis in older adults from developing countries: a cross-validation study using the deuterium dilution method

H Aleman-Mateo et al. J Nutr Health Aging. 2010 Jun.

Abstract

Objective: Several limitations of published bioelectrical impedance analysis (BIA) equations have been reported. The aims were to develop in a multiethnic, elderly population a new prediction equation and cross-validate it along with some published BIA equations for estimating fat-free mass using deuterium oxide dilution as the reference method.

Design and setting: Cross-sectional study of elderly from five developing countries.

Methods: Total body water (TBW) measured by deuterium dilution was used to determine fat-free mass (FFM) in 383 subjects. Anthropometric and BIA variables were also measured. Only 377 subjects were included for the analysis, randomly divided into development and cross-validation groups after stratified by gender. Stepwise model selection was used to generate the model and Bland Altman analysis was used to test agreement.

Results: FFM = 2.95 - 3.89 (Gender) + 0.514 (Ht2/Z) + 0.090 (Waist) + 0.156 (Body weight). The model fit parameters were an R2, total F-Ratio, and the SEE of 0.88, 314.3, and 3.3, respectively. None of the published BIA equations met the criteria for agreement. The new BIA equation underestimated FFM by just 0.3 kg in the cross-validation sample. The mean of the difference between FFM by TBW and the new BIA equation were not significantly different; 95% of the differences were between the limits of agreement of -6.3 to 6.9 kg of FFM. There was no significant association between the mean of the differences and their averages (r= 0.008 and p= 0.2).

Conclusions: This new BIA equation offers a valid option compared with some of the current published BIA equations to estimate FFM in elderly subjects from five developing countries.

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Figures

Figure 1
Figure 1
Good agreement by Bland and Altman procedure Plot of the differences between FFM measured by the TBW method and FFM predicted by the new BIA equation against their averages
Figure 2
Figure 2
Good agreement by Bland and Altman procedure Plot of the differences between FFM measured by the TBW method and FFM predicted by the Kushner's equation against their averages
See this image and copyright information in PMC

References

    1. Alemán-Mateo H., Esparza-Romero J., Romero R.U., García H.A., Pérez Flores F.A., Ochoa Chacón B.V., Valencia M.E. Prevalence of malnutrition and associated metabolic risk factors for cardiovascular disease in older adults from Northwest Mexico. Arch Gerontol Geriatr. 2008;46:375–385. 10.1016/j.archger.2007.05.010 17597234. - DOI - PubMed
    1. Martins I.S., Marinho S.P., de Oliveira D.C., de Araújo E.A. Poverty, malnutrition and obesity: interrelationships among the nutritional status of members of the same family. Cien Saude Colet. 2007;12:1553–1565. 18813492. - PubMed
    1. Dehghan M., Merchant A.T. Is bioelectrical impedance accurate for use in large epidemiological studies. Nutr J. 2008;7:26. 10.1186/1475-2891-7-26 18778488. - DOI - PMC - PubMed
    1. Kyle U.G., Pirlich M., Schuetz T., Luebke H.J., Lochs H., Pichard C. Prevalence of malnutrition in 1760 patients at hospital admission: a controlled population study of body composition. Clin Nutr. 2003;22:473–481. 10.1016/S0261-5614(03)00049-9 14512035. - DOI - PubMed
    1. Broadwin J., Goodman-Gruen D., Slymen D. Ability of fat and fat-free mass percentages to predict functional disability in older men and women. J Am Geriatr Soc. 2001;49:1641–1645. 10.1111/j.1532-5415.2001.49273.x 11843997. - DOI - PubMed

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