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Randomized Controlled Trial
. 2011 Apr;201(4):498-502.
doi: 10.1016/j.amjsurg.2010.02.013. Epub 2010 Jul 8.

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Susumu Eguchi  1 , Mitsuhisa Takatsuki, Masaaki Hidaka, Akihiko Soyama, Tatsuki Ichikawa, Takashi Kanematsu
Affiliations
Free article
Randomized Controlled Trial

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Susumu Eguchi et al. Am J Surg. 2011 Apr.
Free article

Abstract

Background: Although the effect of synbiotic therapy using prebiotics and probiotics has been reported in hepatobiliary surgery, there are no reports of the effect on elective living-donor liver transplantation (LDLT).

Methods: Fifty adult patients undergoing LDLT between September 2005 and June 2009 were randomized into a group receiving 2 days of preoperative and 2 weeks of postoperative synbiotic therapy (Bifidobacterium breve, Lactobacillus casei, and galactooligosaccharides [the BLO group]) and a group without synbiotic therapy (the control group). Postoperative infectious complications were recorded as well as fecal microflora before and after LDLT in each group.

Results: Only 1 systemic infection occurred in the BLO group (4%), whereas the control group showed 6 infectious complications (24%), with 3 cases of sepsis and 3 urinary tract infections with Enterococcus spp (P = .033 vs BLO group). No other type of complication showed any difference between the groups.

Conclusions: Infectious complications after elective LDLT significantly decreased with the perioperative administration of synbiotic therapy.

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