Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;20(12):883-9.
doi: 10.1016/j.annepidem.2010.05.002.

Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study

Lisa Rafalson  1 , Richard P Donahue, Saverio Stranges, Michael J Lamonte, Jacek Dmochowski, Joan Dorn, Maurizio Trevisan
Affiliations

Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study

Lisa Rafalson et al. Ann Epidemiol. 2010 Dec.

Abstract

Purpose: To examine whether sleep duration was associated with incident-impaired fasting glucose (IFG) over 6 years of follow-up in the Western New York Health Study.

Methods: Participants (N = 1,455, 68% response rate) who were free of type 2 diabetes and known cardiovascular disease at baseline (1996-2001) were reexamined in the period 2003-2004. A nested case-control study was conducted. Cases had fasting plasma glucose (FPG) less than 100 mg/dL at baseline and 100 to 125 mg/dL at follow-up: controls (n = 272) had FPG less than 100 mg/dL at both exams. Cases (n = 91) were individually matched to three controls (n = 272) on sex, race, and year of study enrollment. Average sleep duration was categorized as short (<6 hours), mid-range (6 to 8 hours), and long (>8 hours).

Results: In multivariate conditional logistic regression after adjustment for several diabetes risk factors, the odds ratio (OR) of IFG among short sleepers was 3.0 (95% confidence limit [CL]: 1.05, 8.59) compared to mid-range sleepers. There was no association between long sleep and IFG: OR 1.6 (95% CL: 0.45, 5.42). Adjustment for insulin resistance attenuated the association only among short sleepers: OR 2.5 (95% CL: 0.83, 7.46).

Conclusions: Short sleep duration was associated with an elevated risk of IFG. Insulin resistance appears to mediate this association.

PubMed Disclaimer

References

    1. Penev PD. Sleep deprivation and energy metabolism: to sleep, perchance to eat? Current opinion in endocrinology, diabetes, and obesity. 2007;14:374–81. - PubMed
    1. (2005). National Sleep Foundation. “Sleep in America” Poll. Washington DC: National Sleep Foundation; 2005.
    1. Krueger PM, Friedman EM. Sleep duration in the United States: a cross-sectional population-based study. Am J Epidemiol. 2009;169:1052–63. - PMC - PubMed
    1. Broman JE, Lundh LG, Hetta J. Insufficient sleep in the general population. Neurophysiologie Clinique. 1996;26:30–9. - PubMed
    1. Kristen L, Knutson EVC. Associations between Sleep Loss and Increased Risk of Obesity and Diabetes. Annals of the New York Academy of Sciences. 2008;1129:287–304. - PMC - PubMed

Publication types