T helper cell differentiation: understanding the needs of hierarchy
- PMID: 20620936
- DOI: 10.1016/j.immuni.2010.06.008
T helper cell differentiation: understanding the needs of hierarchy
Abstract
In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways.Immunity. 2010 Jun 25;32(6):743-53. doi: 10.1016/j.immuni.2010.06.002. Immunity. 2010. PMID: 20620941 Free PMC article.
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