GPIHBP1: lipoprotein lipase's ticket to ride
- PMID: 20620987
- DOI: 10.1016/j.cmet.2010.06.005
GPIHBP1: lipoprotein lipase's ticket to ride
Abstract
The mechanism of lipoprotein lipase (LPL) transport from muscle and fat cells to the luminal (apical) surface of capillaries, where it hydrolyses lipoprotein triglycerides, has remained undefined. In this issue, Davies et al. (2010) report that GPIHBP1 is required for LPL transcytosis from the basolateral to apical capillary endothelial surface.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.Cell Metab. 2010 Jul 7;12(1):42-52. doi: 10.1016/j.cmet.2010.04.016. Cell Metab. 2010. PMID: 20620994 Free PMC article.
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