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Review
. 2010 Sep;299(3):H577-83.
doi: 10.1152/ajpheart.00421.2010. Epub 2010 Jul 9.

The mitochondrial component of intracrine action

Richard N Re  1 , Julia L Cook
Affiliations
Review

The mitochondrial component of intracrine action

Richard N Re et al. Am J Physiol Heart Circ Physiol. 2010 Sep.

Abstract

In recent years the actions of intracellular-acting, extracellular signaling proteins/peptides (intracrines) have become increasingly defined. General principles of intracrine action have been proposed. Mitochondria represent one locus of intracrine action, and thus far, angiotensin II, transforming growth factor-beta, growth hormone, atrial natriuretic peptide, Wnt 13, stanniocalcin, other renin-angiotensin system components, and vascular endothelial-derived growth factor, among others, have been shown to be mitochondria-localizing intracrines. The implications of this mitochondrial intracrine biology are discussed.

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