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Randomized Controlled Trial
. 2010 Sep;87(9):631-41.
doi: 10.1097/OPX.0b013e3181ea19c7.

Spectacle lenses designed to reduce progression of myopia: 12-month results

Padmaja Sankaridurg  1 , Leslie Donovan, Saulius Varnas, Arthur Ho, Xiang Chen, Aldo Martinez, Scott Fisher, Zhi Lin, Earl L Smith 3rd, Jian Ge, Brien Holden
Affiliations
Randomized Controlled Trial

Spectacle lenses designed to reduce progression of myopia: 12-month results

Padmaja Sankaridurg et al. Optom Vis Sci. 2010 Sep.

Erratum in

  • Optom Vis Sci. 2010 Oct;87(10):802

Abstract

Purpose: To report the results of 12-month wear of three novel spectacle lens designs intended to reduce peripheral hyperopic defocus and one standard design control lens and their effect on the progression of myopia in Chinese children aged 6 to 16 years.

Methods: Chinese children (n = 210) with myopia (-0.75 D to -3.50 D sphere, cylinder <or=-1.50 D) were randomized to one of four groups wearing either one of three novel spectacle lens designs (types I, II, or III) or conventional, single-vision spectacle lenses. Data were collected at 6 and 12 months. Primary and secondary outcome measures were the changes in central cycloplegic auto-refraction and eye axial length, respectively. Peripheral refraction along the horizontal meridian (nasal and temporal) was taken at baseline with and without spectacle lenses. Multivariate linear regression was used to adjust analyses for important covariates.

Results: Progression in eyes wearing control spectacle lenses at 6 and 12 months was -0.55 D +/- 0.35 D and -0.78 +/- 0.50 D, respectively. For the entire group, no statistically significant differences were observed in the rates of progression with the novel designs in comparison to control spectacle lenses. However, in younger children (6 to 12 years) with parental history of myopia (n = 100), there was significantly less progression (-0.68 D +/- 0.47 D vs. -0.97 D +/- 0.48 D) with lens type III compared with control spectacles (mean difference, 0.29 D, std error, 0.11, p = 0.038).

Conclusions: There were no statistically significant differences in the rate of progression of myopia between the control and novel lens wearing eyes for the age group 6 to 16 years. The finding of reduced progression of myopia with type III lens design in younger children with parental myopia needs to be validated in a more targeted study.

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Figures

FIGURE 1
FIGURE 1
Participant flow in the study.
FIGURE 2
FIGURE 2
Progression in myopia plotted as the change in mean spherical equivalent (M) with time for all subjects. Error bars are standard deviations.
FIGURE 3
FIGURE 3
Change in axial length with time for all subjects. Error bars are standard deviations.
FIGURE 4
FIGURE 4
Central and peripheral mean spherical equivalent (M) component of refractive errors with (gray lines) and without correction (dark lines) for all subjects. Error bars are standard deviations.
FIGURE 5
FIGURE 5
Change in mean spherical equivalent (M) for subjects aged 6 to 12 years. Error bars are standard deviations.
FIGURE 6
FIGURE 6
Change in axial length for subjects aged 6 to 12 years. Error bars are standard deviations.
FIGURE 7
FIGURE 7
Central and peripheral mean spherical equivalent (M) component of refractive errors with (gray lines) and without correction (dark lines) for 6- to 12-year-old subjects. Error bars are standard deviations.
See this image and copyright information in PMC

References

    1. Shih YF, Chiang TH, Lin LL. Lens thickness changes among school-children in Taiwan. Invest Ophthalmol Vis Sci. 2009;50:2637–44. - PubMed
    1. Lin LL, Shih YF, Hsiao CK, Chen CJ, Lee LA, Hung PT. Epidemiologic study of the prevalence and severity of myopia among school-children in Taiwan in 2000. J Formos Med Assoc. 2001;100:684–91. - PubMed
    1. Xu L, Wang Y, Wang S, Jonas JB. High myopia and glaucoma susceptibility the Beijing Eye Study. Ophthalmology. 2007;114:216–20. - PubMed
    1. Congdon N, Wang Y, Song Y, Choi K, Zhang M, Zhou Z, Xie Z, Li L, Liu X, Sharma A, Wu B, Lam DS. Visual disability, visual function, and myopia among rural Chinese secondary school children: the Xichang Pediatric Refractive Error Study (X-PRES)–report 1. Invest Ophthalmol Vis Sci. 2008;49:2888–94. - PubMed
    1. Lim MC, Gazzard G, Sim EL, Tong L, Saw SM. Direct costs of myopia in Singapore. Eye (Lond) 2009;23:1086–9. - PubMed

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